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  • VLL-28 peptide

    For research use only. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.

    Catalog Number: MPE0008931

    Product Quantity: 5mg/20mg

    Price: Varies

    Availability: In Stock

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    Product Information

    The antimicrobial peptide VLL-28, isolated from an archaeal transcription factor, shows comparable antifungal activity against 10 clinical isolates of Candida spp. VLL-28 binds to the surface of planktonic cells. VLL-28 effectively reduced the viability of the cells embedded in the mature biofilms, with MBEC50 and MBEC80 of 50 μM and 100 μM, respectively, for C. albicans isolates and the reference strain. In addition, VLL-28 killed 50% of the cells in the preformed biofilm (MBEC50) of C. glabrata and C. parapsilosis isolates at a concentration of 100 μM. On the other hand, VLL-28 was less effective against the mature biofilms of C. tropicalis and C. krusei isolates. VLL-28 is a cryptic antimicrobial peptide derived from a transcriptional factor of Sulfolobus islandicus. VLL-28 displayed a reduced activity only towards C. glabrata, which showed the highest MIC and MFC values . VLL-28 also exhibited strong fungicidal activity towards the planktonic cells of C. krusei. VLL-28 interacts primarily with the fungal surfaces. VLL-28 behaves as a typical CAMP by damaging the cell membrane and/or the cell wall, thus, greatly decreasing the likelihood of the appearance of strains resistance.

    Product Name: VLL-28 peptide
    Molecular Formula: C163H264N54O35
    Molecular Weight: 3540.17
    Sequence: H-VLLVTLTRLHQRGVIYRKWRHFSGRKYR-OH
    Three letter code: H-Val-Leu-Leu-Val-Thr-Leu-Thr-Arg-Leu-His-Gln-Arg-Gly-Val-Ile-Tyr-Arg-Lys-Trp-Arg-His-Phe-Ser-Gly-Arg-Lys-Tyr-Arg-OH
    Length (aa): 33
    Peptide Purity (HPLC): >95%; 98% and 99% purity available upon request
    Quantity/Unit: 1 Vial
    * Optional Service: TFA Removal Service is available upon request.

    Technical Information

    Source: Synthetic
    Storage Guidelines: Store at -20°C for up to 1 year. should be refrigerated after reconstitution. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
    Solubility: Soluble in water
    Appearance: White to off-white powder
    Shipping: Peptides are shipped at ambient temperature by standard shipment process.
    About TFA salt: Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.
    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others. It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.
    TFA Removal Service is recommended for: > Peptides that will be used in cellular assays > Peptides that will be used as APIs or in manufactured products > For hydrophilic peptides containing numerous basic residues

    Related Products / Services

    Custom Peptide Synthesis:   VLL-28 peptide peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression. Read more...

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