Transferrin Receptor Targeting Peptide T12
For research use only. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.
Catalog Number: MPE0008465
Product Quantity: 5mg/20mg
Price: Varies
Availability: In Stock
Product Information
Transferrin receptor (TfR), is a transmembrane glycoprotein involved in cellular iron trafficking after interaction with its native iron-rich ligand, transferrin (Tf). Of the two TfR subtypes, theTfR2 is abundantly expressed in glioblastomas and their associated vasculature. Using the M13-phage screening on chicken embryo fibroblasts constitutively expressing the human transferrin receptor (hTfR), peptides T7 (HAIYPRH) and T12 (THRPPMWSPVWP) were discovered. Both peptides have been widely used to target several cancer types overexpressing transferrin receptors (TfR1 and TfR2), including liver, prostate, breast, pancreatic cancers, and many others. T12 showed higher affinity, in nanomolar range, towards the target and appeared more promising than the T7 peptide. However, T12 failed to show enhanced transport of conjugated compounds across the BBB.
| Product Name: | Transferrin Receptor Targeting Peptide T12 |
| Molecular Formula: | C71H99N19O15S |
| Molecular Weight: | 1490.72 |
| Sequence: | H-THRPPMWSPVWP-OH |
| Three letter code: | H-Thr-His-Arg-Pro-Pro-Met-Trp-Ser-Pro-Val-Trp-Pro-OH |
| Length (aa): | 17 |
| Peptide Purity (HPLC): | >95%; 98% and 99% purity available upon request |
| Quantity/Unit: | 1 Vial |
| * Optional Service: | TFA Removal Service is available upon request. |
Technical Information
| Source: | Synthetic |
| Storage Guidelines: | Store at -20°C for up to 1 year. should be refrigerated after reconstitution. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides |
| Solubility: | Soluble in water |
| Appearance: | White to off-white powder |
| Shipping: | Peptides are shipped at ambient temperature by standard shipment process. |
| About TFA salt: | Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA. TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others. It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR. TFA Removal Service is recommended for: > Peptides that will be used in cellular assays > Peptides that will be used as APIs or in manufactured products > For hydrophilic peptides containing numerous basic residues |
Related Products / Services
Custom Peptide Synthesis: Transferrin Receptor Targeting Peptide T12 peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression. Read more...
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