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    Temporin-GHa (GHa) peptide

    For research use only. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.

    Catalog Number: MPE0010923

    Product Quantity: 5mg/20mg

    Price: Varies

    Availability: In Stock

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    Product Information

    The abuse of antibiotics has led to the emergence of multidrug-resistant bacteria, which isbecoming a serious worldwide problem people have to face. In our previous study, temporin-GHa(GHa) cloned from Hylarana guentheri showed antimicrobial activity against Gram-positive bacteria.In order to improve its therapeutic potential, we used a template-based and a database-assisteddesign to obtain three derived peptides by replacing the histidine at both ends of GHa with lysine,which exhibited faster and stronger bactericidal activity and a broader spectrum than the parentpeptide. GHaK and GHa4K targeted to the bacterial membrane to exert their antibacterial activitiesat a faster membrane damage rate. The derived peptides inhibited the initial adhesion and theformation of Staphylococcus aureus biofilms, and eradicated the mature biofilms, which indicated thatthe derived peptides effectively penetrated the biofilm and killed bacteria. The therapeutic index (TI)and cell selectivity index (CSI) of the derived peptides increased significantly, which means a broadertherapeutic window of the derived peptides. The derived peptides with improved activity and cellselectivity have the potential to be the promising candidates for the treatment of S. aureus infections.Our research also provides new insights into the design and development of antimicrobial peptides.

    Product Name: Temporin-GHa (GHa) peptide
    Molecular Formula: C72H108N18O15
    Molecular Weight: 1465.73
    Sequence: H-FLQHIIGALGHLF-OH
    Three letter code: H-Phe-Leu-Gln-His-Ile-Ile-Gly-Ala-Leu-Gly-His-Leu-Phe-OH
    Length (aa): 18
    Peptide Purity (HPLC): >95%; 98% and 99% purity available upon request
    Quantity/Unit: 1 Vial
    * Optional Service: TFA Removal Service is available upon request.

    Technical Information

    Source: Synthetic
    Storage Guidelines: Store at -20°C for up to 1 year. should be refrigerated after reconstitution. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
    Solubility: Soluble in water
    Appearance: White to off-white powder
    Shipping: Peptides are shipped at ambient temperature by standard shipment process.
    About TFA salt: Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.
    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others. It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.
    TFA Removal Service is recommended for: > Peptides that will be used in cellular assays > Peptides that will be used as APIs or in manufactured products > For hydrophilic peptides containing numerous basic residues

    Related Products / Services

    Custom Peptide Synthesis:   Temporin-GHa (GHa) peptide peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression. Read more...

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