Ranatuerin-2Pb peptide
For research use only. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.
Catalog Number: MPE0000771
Product Quantity: 5mg/20mg
Price: Varies
Availability: In Stock
Product Information
Ranatuerin-2Pb is an antimicrobial peptide identified from Frog Skin Secretion of Rana pipiens. Ranatuerin-2Pb exhibited broad-spectrum antimicrobial activity. Ranatuerin-2Pb exhibited strong antimicrobial activity against S. aureus, E. coli, C. albicans and MRSA; however, it showed no inhibition activity against E. faecalis and P. aeruginosa. Ranatuerin-2Pb exhibited a hemolysis rate near 20% on horse erythrocytes with the concentration at 8uM. The HC50 of ranatuerin-2Pb was 16.11 uM. Ranatuerin-2Pb showed antibiofilm activity against S. aureus, E. coli and C. albicans. Ranatuerin-2Pb exhibited significant inhibitory effect on the proliferation of NCI-H157, MCF-7, U251MG and PC-3, with the IC50 value of 1.453 µM, 7.254 µM, 2.172 µM and 2.251 µM, respectively. Ranatuerin-2Pb showed no inhibitory effect on the proliferation of MDA-MB-435s. Ranatuerin-2Pb induced the highest degree of LDH release for H157 among three peptides.
| Product Name: | Ranatuerin-2Pb peptide |
| Molecular Formula: | C155H272N42O46S2 |
| Molecular Weight: | 3524.18 |
| Sequence: | H-SFLTTVKKLVTNLAALAGTVIDTIKCKVTGGCRT-OH |
| Three letter code: | H-Ser-Phe-Leu-Thr-Thr-Val-Lys-Lys-Leu-Val-Thr-Asn-Leu-Ala-Ala-Leu-Ala-Gly-Thr-Val-Ile-Asp-Thr-Ile-Lys-Cys-Lys-Val-Thr-Gly-Gly-Cys-Arg-Thr-OH |
| Length (aa): | 39 |
| Peptide Purity (HPLC): | >95%; 98% and 99% purity available upon request |
| Quantity/Unit: | 1 Vial |
| * Optional Service: | TFA Removal Service is available upon request. |
Technical Information
| Source: | Synthetic |
| Storage Guidelines: | Store at -20°C for up to 1 year. should be refrigerated after reconstitution. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides |
| Solubility: | Soluble in water |
| Appearance: | White to off-white powder |
| Shipping: | Peptides are shipped at ambient temperature by standard shipment process. |
| About TFA salt: | Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA. TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others. It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR. TFA Removal Service is recommended for: > Peptides that will be used in cellular assays > Peptides that will be used as APIs or in manufactured products > For hydrophilic peptides containing numerous basic residues |
Related Products / Services
Custom Peptide Synthesis: Ranatuerin-2Pb peptide peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression. Read more...
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