Ps-CATH4 peptide
For research use only. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.
Catalog Number: MPE0001649
Product Quantity: 5mg/20mg
Price: Varies
Availability: In Stock
Product Information
Cathelicidins are a class of gene-encoded immune effectors in vertebrate innate immune system. Ps-CATH4 is a novel cathelicidin which was found in Chinese soft-shell turtle (Pelodiscus sinensis). Ps-CATH4 was expressed in lung, spleen, liver, kidney, muscle, stomach and intestine. Ps-CATH4 showed the most potent and broad-spectrum antimicrobial activities against the tested pathogens, with the MICs mainly ranging from 2.34 μg/ml to 18.75 μg/ml. Ps-CATH6 showed relatively low antimicrobial activity. Ps-CATH4 and 6 showed relatively low cytotoxicity towards RAW264.7 cells, inducing 15.95% and 10.98% cell death, respectively. Ps-CATH4 showed more potent membrane permeabilization effect than Ps-CATH6, which is consistent with their different antimicrobial activities.
| Product Name: | Ps-CATH4 peptide |
| Molecular Formula: | C175H291N65O38 |
| Molecular Weight: | 3913.58 |
| Sequence: | H-TRGRWGRFKRRAGRFIRRNRWQIISTGLKLIG-OH |
| Three letter code: | H-Thr-Arg-Gly-Arg-Trp-Gly-Arg-Phe-Lys-Arg-Arg-Ala-Gly-Arg-Phe-Ile-Arg-Arg-Asn-Arg-Trp-Gln-Ile-Ile-Ser-Thr-Gly-Leu-Lys-Leu-Ile-Gly-OH |
| Length (aa): | 37 |
| Peptide Purity (HPLC): | >95%; 98% and 99% purity available upon request |
| Quantity/Unit: | 1 Vial |
| * Optional Service: | TFA Removal Service is available upon request. |
Technical Information
| Source: | Synthetic |
| Storage Guidelines: | Store at -20°C for up to 1 year. should be refrigerated after reconstitution. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides |
| Solubility: | Soluble in water |
| Appearance: | White to off-white powder |
| Shipping: | Peptides are shipped at ambient temperature by standard shipment process. |
| About TFA salt: | Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA. TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others. It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR. TFA Removal Service is recommended for: > Peptides that will be used in cellular assays > Peptides that will be used as APIs or in manufactured products > For hydrophilic peptides containing numerous basic residues |
Related Products / Services
Custom Peptide Synthesis: Ps-CATH4 peptide peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression. Read more...
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