PL-101 peptide
For research use only. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.
Catalog Number: MPE0004743
Product Quantity: 5mg/20mg
Price: Varies
Availability: In Stock
Product Information
In the sequence of the natural plicatamide, the last residue is decarboxy-(E)-alpha,beta-dehydro-3,4-dihydroxyphenylalanine (dopa), which Y is found to be a close mimic of. The native peptide and PL-101 had similar activity against Gram-positive S. aureus and L. monocytogenes. However, the native form appeared to be 2-3 fold more active against Gram-negative bacteria such as E. coli and P. aeruginosa. The native form is also hemolytic. Interestingly, another two natural compounds, 5-S-GAD (Leem JY et al. 1996 J Biol Chem 271: 13573-77) and halocyamine A (Azumi K et al 1990 Biochemistry 29: 159-65), also possess the DOPA unit. Another derivative is PL-135 (seq: FHFHLHF). When linked to a targeting sequence by a linker (to generate a STAMP), the activity of PL-135 was found to reduce by 2-8 fold (He et al. 2010 AAC 54: 2143). Thus, whether the STAMP strategy (Eckert et al 2006 AAC 50: 3833) will work is AMP dependent. PL-101 has Antibacterial activity. The source of PL-101 is Styela plicata.
| Product Name: | PL-101 peptide |
| Sequence: | FFHLHFHY |
| Three letter code: | Phe-Phe-His-Leu-His-Phe-His-Tyr |
| Length (aa): | 8 |
| Peptide Purity (HPLC): | >95%; 98% and 99% purity available upon request |
| Quantity/Unit: | 1 Vial |
| * Optional Service: | TFA Removal Service is available upon request. |
Technical Information
| Source: | Synthetic |
| Storage Guidelines: | Store at -20°C for up to 1 year. should be refrigerated after reconstitution. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides |
| Solubility: | Soluble in water |
| Appearance: | White to off-white powder |
| Shipping: | Peptides are shipped at ambient temperature by standard shipment process. |
| About TFA salt: | Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA. TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others. It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR. TFA Removal Service is recommended for: > Peptides that will be used in cellular assays > Peptides that will be used as APIs or in manufactured products > For hydrophilic peptides containing numerous basic residues |
Related Products / Services
Custom Peptide Synthesis: PL-101 peptide peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression. Read more...
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