Penetratin peptide
For research use only. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.
Catalog Number: MPE0004410
Product Quantity: 5mg/20mg
Price: Varies
Availability: In Stock
Product Information
Penetratin, a 16-mer Drosophila Antennapedia derived peptide, like TAT, crosses the biological membranes and is transported to the nucleus of the cells. The interaction between penetratin (P16; RQIKIWFQNRRMKWKK) and phospholipid bicelles mimicking biological membranes was studied by NMR spectroscopy. The secondary structure and positioning studies confirmed the two tryptophan residues (48W and 56W) as the most important amino acids required for cellular internalization . The P16 or its shortened variant P7 (RRMKWKK) has been utilized to promote cellular uptake of impermeable targeting peptides such as G7-18NATE. Antitumor efficacy and translocation across the BBB of liposomes or liposome encapsulated drugs (doxorubicin and erlotinib) were evaluated using the in vitro BBB and intracranial glioblastoma xenograft models. Dual conjugation of penetratin and transferrin to liposomes (Tf-Pen-Lipo) significantly enhanced the BBB translocation. In addition, doxorubicin/erlotinib containing Tf-Pen-Liposomes very significantly accumulated in tumors, inhibited tumor growth, and prolonged survival rate when compared to the free drugs.
| Product Name: | Penetratin peptide |
| Molecular Formula: | C104H168N34O20S |
| Molecular Weight: | 2246.72 |
| Sequence: | H-RQIKIWFQNRRMKWKK-OH |
| Three letter code: | H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH |
| Length (aa): | 21 |
| Peptide Purity (HPLC): | >95%; 98% and 99% purity available upon request |
| Quantity/Unit: | 1 Vial |
| * Optional Service: | TFA Removal Service is available upon request. |
Technical Information
| Source: | Synthetic |
| Storage Guidelines: | Store at -20°C for up to 1 year. should be refrigerated after reconstitution. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides |
| Solubility: | Soluble in water |
| Appearance: | White to off-white powder |
| Shipping: | Peptides are shipped at ambient temperature by standard shipment process. |
| About TFA salt: | Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA. TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others. It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR. TFA Removal Service is recommended for: > Peptides that will be used in cellular assays > Peptides that will be used as APIs or in manufactured products > For hydrophilic peptides containing numerous basic residues |
Related Products / Services
Custom Peptide Synthesis: Penetratin peptide peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression. Read more...
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