PE1 peptide
For research use only. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.
Catalog Number: MPE0000601
Product Quantity: 5mg/20mg
Price: Varies
Availability: In Stock
Product Information
An N-terminal lipidated cyclic antibiotic with nonstandard amino acid Dab at positions 1, 3, and 6 (Dab, 2,4-diaminobutanoic acid, is two CH2 units less than lysine, although represented by K here in the sequence), D-amino acids for F4 and V7. The ring structure is proposed to occur between the C-terminal carboxylic and hydroxyl group of the N-terminal fatty acid portion. PE1 and PE2 share the same peptide backbone but have different fatty acid chains (C-end-OCHRCH2CO-N-end: R is C4H9 for PE1 and C3H7 for PE2). Because of the same amino acid sequence, PE1 and PE2 share this AP number. Both compounds are active against S. epidermidis CMCC 26069, S. aureus ATCC 25923, S. aureus ATCC 43300, E. coli ATCC 35318, E. coli 5539, P. aeruginosa ATCC 27853, P. aeruginosa 5215, and fungus C. albicans ATCC 10231 (MIC 1-8 ug/ml), better than polymyxin B in certain cases. The source of PE1 is Paenibacillus ehimensis B7.
| Product Name: | PE1 peptide |
| Sequence: | KIKFLKVLT |
| Three letter code: | Lys-Ile-Lys-Phe-Leu-Lys-Val-Leu-Thr |
| Length (aa): | 9 |
| Peptide Purity (HPLC): | >95%; 98% and 99% purity available upon request |
| Quantity/Unit: | 1 Vial |
| * Optional Service: | TFA Removal Service is available upon request. |
Technical Information
| Source: | Synthetic |
| Storage Guidelines: | Store at -20°C for up to 1 year. should be refrigerated after reconstitution. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides |
| Solubility: | Soluble in water |
| Appearance: | White to off-white powder |
| Shipping: | Peptides are shipped at ambient temperature by standard shipment process. |
| About TFA salt: | Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA. TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others. It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR. TFA Removal Service is recommended for: > Peptides that will be used in cellular assays > Peptides that will be used as APIs or in manufactured products > For hydrophilic peptides containing numerous basic residues |
Related Products / Services
Custom Peptide Synthesis: PE1 peptide peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression. Read more...
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