PaDBS1R6F10 peptide

Bacterial biofilms and associated infectionsrepresent one of the biggest challenges in the clinic, and asan alternative to counter bacterial infections, antimicrobialpeptides have attracted great attention in the past decade.Here, ten short cationic antimicrobial peptides were generatedthrough a sliding-window strategy on the basis of the 19-amino acid residue peptide, derived from a Pyrobaculumaerophilum ribosomal protein. PaDBS1R6F10 exhibited antiinfectivepotential as it decreased the bacterial burden inmurine Pseudomonas aeruginosa cutaneous infections by morethan 1000-fold. Adverse cytotoxic and hemolytic effects werenot detected against mammalian cells. The peptide demonstratedstructural plasticity in terms of its secondary structure in the different environments tested. PaDBS1R6F10 represents apromising antimicrobial agent against bacteria infections, without harming human cells.