Nap-GFFKEH, Nap-1 peptide
For research use only. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.
Catalog Number: MPE0000870
Product Quantity: 5mg/20mg
Price: Varies
Availability: In Stock
Product Information
Nap-1 is a noval class of histidine-containing hexapeptide derivatives used for in situ hydrogelation at the zinc ion-rich prostate tissue. Nap-1 displayed excellent self-assembly capability with a high sensitivity to zinc ions at about 0.1 equivalency. The molecular was rationally designed: (1) a dipeptide of phenylalanine (FF) which was utilized to promote molecular self-assembly and gelation; (2) a capping group of naphthalene to tune the hydrophobicity of Nap-1; (3) a terminus with glutamate (E) and histidine (H) to tune the hydrophilicity and to chelate zinc ions to form coordination bonds. Nap-1 was soluble in PBS and would form hydrogels at physiological pH (~pH 7.2) in the presence of zinc ions. The addition of 0.34 equiv. of EDTA destroyed the as-formed hydrogels of Nap-1 in 30 seconds, proving that metal chelations between zinc ions and peptides were vital for the self-assembly process.
| Product Name: | Nap-GFFKEH, Nap-1 peptide |
| Molecular Formula: | C49H57N9O10 |
| Molecular Weight: | 932.03 |
| Sequence: | Nap-GFFKEH |
| Three letter code: | naphthylacetic acid-Gly-Phe-Phe-Lys-Glu-His |
| Length (aa): | 10 |
| Peptide Purity (HPLC): | >95%; 98% and 99% purity available upon request |
| Quantity/Unit: | 1 Vial |
| * Optional Service: | TFA Removal Service is available upon request. |
Technical Information
| Source: | Synthetic |
| Storage Guidelines: | Store at -20°C for up to 1 year. should be refrigerated after reconstitution. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides |
| Solubility: | Soluble in water |
| Appearance: | White to off-white powder |
| Shipping: | Peptides are shipped at ambient temperature by standard shipment process. |
| About TFA salt: | Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA. TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others. It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR. TFA Removal Service is recommended for: > Peptides that will be used in cellular assays > Peptides that will be used as APIs or in manufactured products > For hydrophilic peptides containing numerous basic residues |
Related Products / Services
Custom Peptide Synthesis: Nap-GFFKEH, Nap-1 peptide peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression. Read more...
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