LF11-227 peptide
For research use only. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.
Catalog Number: MPE0002509
Product Quantity: 5mg/20mg
Price: Varies
Availability: In Stock
Product Information
Acylation of antimicrobial peptides mimics the structure of the natural lipopeptidepolymyxin B, and increases antimicrobial and endotoxin-neutralizing activities. In this study, theantimicrobial properties of lactoferrin-based LF11 peptides as well as blood compatibility as a functionof acyl chain length were investigated. Beyond the classical hemolysis test, the biocompatibilitywas determined with human leukocytes and platelets, and the influence of antimicrobial peptides(AMPs) on the plasmatic coagulation and the complement system was investigated. The results ofthis study show that the acylation of cationic peptides significantly reduces blood tolerance. Withincreasing acyl chain length, the cytotoxicity of LF11 peptides to human blood cells also increased.This study also shows that acylated cationic antimicrobial peptides are inactivated by the presence ofheparin. In addition, it could be shown that the immobilization of LF11 peptides leads to a loss oftheir antimicrobial properties.
| Product Name: | LF11-227 peptide |
| Molecular Formula: | C64H89N23O8 |
| Molecular Weight: | 1308.54 |
| Sequence: | H-FWRRFWRR-Amidation |
| Three letter code: | H-Phe-Trp-Arg-Arg-Phe-Trp-Arg-Arg-Amidation |
| Length (aa): | 20 |
| Peptide Purity (HPLC): | >95%; 98% and 99% purity available upon request |
| Quantity/Unit: | 1 Vial |
| * Optional Service: | TFA Removal Service is available upon request. |
Technical Information
| Source: | Synthetic |
| Storage Guidelines: | Store at -20°C for up to 1 year. should be refrigerated after reconstitution. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides |
| Solubility: | Soluble in water |
| Appearance: | White to off-white powder |
| Shipping: | Peptides are shipped at ambient temperature by standard shipment process. |
| About TFA salt: | Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA. TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others. It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR. TFA Removal Service is recommended for: > Peptides that will be used in cellular assays > Peptides that will be used as APIs or in manufactured products > For hydrophilic peptides containing numerous basic residues |
Related Products / Services
Custom Peptide Synthesis: LF11-227 peptide peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression. Read more...
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