Interleukin-4 Receptor Targeting Peptide AP
For research use only. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.
Catalog Number: MPE0004130
Product Quantity: 5mg/20mg
Price: Varies
Availability: In Stock
Product Information
Atherosclerotic plaque (AP) homing nonapeptide (CRKRLDRNC) was identified after cycles of ex vivo phage display screening on human atheroma tissue and further validated for homing to the atherosclerotic plaques in an in vivo murine model. A homology sequence search identified the AP binding sequence KRLDRN motif corresponding to the Interleukin-4 (IL-4) . Its receptor, IL-4R, is abundantly expressed by glioma cells thereby presenting the CRKRLDRNC as a promising tool for glioma targeting. Park et al. showed promising results with the AP peptide conjugated to doxorubicin containing microbubbles and nanoliposomes as a proof-of-concept for glioma targeted imaging and therapy using the U87MG in vitro models. AP peptide conjugated to doxorubicin containing liposomes showed also enhanced antitumor activity in in vivo model of human lung cancer.
| Product Name: | Interleukin-4 Receptor Targeting Peptide AP |
| Molecular Formula: | C44H82N20O13S2 |
| Molecular Weight: | 1163.37 |
| Sequence: | H-CRKRLDRNC-OH |
| Three letter code: | H-Cys-Arg-Lys-Arg-Leu-Asp-Arg-Asn-Cys-OH |
| Length (aa): | 14 |
| Peptide Purity (HPLC): | >95%; 98% and 99% purity available upon request |
| Quantity/Unit: | 1 Vial |
| * Optional Service: | TFA Removal Service is available upon request. |
Technical Information
| Source: | Synthetic |
| Storage Guidelines: | Store at -20°C for up to 1 year. should be refrigerated after reconstitution. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides |
| Solubility: | Soluble in water |
| Appearance: | White to off-white powder |
| Shipping: | Peptides are shipped at ambient temperature by standard shipment process. |
| About TFA salt: | Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA. TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others. It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR. TFA Removal Service is recommended for: > Peptides that will be used in cellular assays > Peptides that will be used as APIs or in manufactured products > For hydrophilic peptides containing numerous basic residues |
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Custom Peptide Synthesis: Interleukin-4 Receptor Targeting Peptide AP peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression. Read more...
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