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    HEXIM1 peptide (BR-RRR12)

    For research use only. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.

    Catalog Number: MPE0003110

    Product Quantity: 5mg/20mg

    Price: Varies

    Availability: In Stock

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    Product Information

    The emergence of antibiotic resistant bacteria is one of the biggest threats tohuman health worldwide. In 2017, World Health Organization listed the world’s mostdangerous antibiotic-resistant bacteria or “superbugs,” such as carbapenem-resistantPseudomonas aeruginosa and Escherichia coli, indicating the highest priority needs fornew antibiotics. The possibility that such infectious diseases may soon be untreatable,due to decreased antibiotic efficacy, creates an urgent need for novel and alternativeantimicrobials. Antimicrobial peptides are naturally occurring small molecules found inthe innate immunity of mammals, plants and bacteria, and are potentially therapeuticcandidates against drug-resistant bacteria. In this study, we examine the antimicrobialactivities of the cytotoxic peptides derived from the basic region (BR) of the humanhexamethylene bisacetamide-inducible protein 1 (HEXIM1). We found that, when fusedwith a cell penetrating peptide, the HEXIM1 BR peptide and its derivative, BR-RRR12,exhibited inhibitory activities against selected “superbugs.” Negligible effects on theviability of human keratinocyte cell line were observed when the bactericidal dosagesof HEXIM1 BR peptides were used. Different killing kinetics were observed between themembrane permeabilizing antimicrobial peptides and HEXIM1 BR peptides, suggestingthat a different antimicrobial mechanism might be utilized by the HEXIM1 BR peptides.Using an in vitro translation system based on E. coli lysates, we found that HEXIM1BR peptides blocked bacterial translation. Taken together, we identify the HEXIM1BR peptide as a novel antimicrobial peptide with potent inhibitory activity againstantibiotic-resistant “superbugs.”

    Product Name: HEXIM1 peptide (BR-RRR12)
    Molecular Formula: C104H180N54O21
    Molecular Weight: 2522.88
    Sequence: H-QLGRRRHRRRPSRRRRHW-OH
    Three letter code: H-Gln-Leu-Gly-Arg-Arg-Arg-His-Arg-Arg-Arg-Pro-Ser-Arg-Arg-Arg-Arg-His-Trp-OH
    Length (aa): 23
    Peptide Purity (HPLC): >95%; 98% and 99% purity available upon request
    Quantity/Unit: 1 Vial
    * Optional Service: TFA Removal Service is available upon request.

    Technical Information

    Source: Synthetic
    Storage Guidelines: Store at -20°C for up to 1 year. should be refrigerated after reconstitution. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
    Solubility: Soluble in water
    Appearance: White to off-white powder
    Shipping: Peptides are shipped at ambient temperature by standard shipment process.
    About TFA salt: Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.
    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others. It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.
    TFA Removal Service is recommended for: > Peptides that will be used in cellular assays > Peptides that will be used as APIs or in manufactured products > For hydrophilic peptides containing numerous basic residues

    Related Products / Services

    Custom Peptide Synthesis:   HEXIM1 peptide (BR-RRR12) peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression. Read more...

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