Fz7-21, a peptide antagonist for FZD7 receptor subclass
For research use only. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.
Catalog Number: MPE0002386
Product Quantity: 5mg/20mg
Price: Varies
Availability: In Stock
Product Information
The Fz7-21 (amino acid sequence: acetyl (Ac)-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val-Met-Tyr-NH2), impaired Wnt–β-catenin signaling in HEK293 cells that were stimulated with exogenous WNT3A or transfected with a construct expressing WNT3A or WNT1; it also blocked WNT3A-mediated stabilization of β -catenin in mouse L cells20 (IC50 = 50 nM), although the maximum inhibition reached a plateau at 50%. The observed difference in maximum Wnt pathway inhibition between HEK293 and mouse L cells, as measured by a Wnt-dependent luciferase reporter and β -catenin imaging assays, respectively, could likely be due to differences in cell surface expression levels of various FZD receptors across different cell lines.
| Product Name: | Fz7-21, a peptide antagonist for FZD7 receptor subclass |
| Molecular Formula: | C83H114N18O23S2 |
| Molecular Weight: | 1796.02 |
| Sequence: | Ac-LPSDDLEFWCHVMY-NH2 |
| Three letter code: | (Ac)-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val-Met-Tyr-NH2 |
| Length (aa): | 21 |
| Peptide Purity (HPLC): | >95%; 98% and 99% purity available upon request |
| Quantity/Unit: | 1 Vial |
| * Optional Service: | TFA Removal Service is available upon request. |
Technical Information
| Source: | Synthetic |
| Storage Guidelines: | Store at -20°C for up to 1 year. should be refrigerated after reconstitution. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides |
| Solubility: | Soluble in water |
| Appearance: | White to off-white powder |
| Shipping: | Peptides are shipped at ambient temperature by standard shipment process. |
| About TFA salt: | Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA. TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others. It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR. TFA Removal Service is recommended for: > Peptides that will be used in cellular assays > Peptides that will be used as APIs or in manufactured products > For hydrophilic peptides containing numerous basic residues |
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Custom Peptide Synthesis: Fz7-21, a peptide antagonist for FZD7 receptor subclass peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression. Read more...
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