ES2 peptide
For research use only. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.
Catalog Number: MPE0007495
Product Quantity: 5mg/20mg
Price: Varies
Availability: In Stock
Product Information
ES2 can act as senolytics for eliminating senescent human cancer cells both in cell culture and in orthotopic mouse models. It disrupts FOXO4-TP53 foci, activates TP53 mediated apoptosis and preferentially binds FOXO4 compared to TP53. Intratumoural delivery of ES2 plus a BRAF inhibitor results in a significant increase in apoptosis and a survival advantage in mouse models of melanoma. Repeated systemic delivery of ES2 to older mice results in reduced senescent cell numbers in the liver with minimal toxicity. When compared with FOXO4-DRI peptide and found that, while FOXO4-DRI has minimal lytic activity in dividing cells, ES2 peptide had 3-7 times higher senolytic activity
| Product Name: | ES2 peptide |
| Molecular Formula: | C190H355N101O37 |
| Molecular Weight: | 4646.49 |
| Sequence: | H-PRKGGRRRRAWGRRRRRRRRRRRRRRAPRKRLTLA-OH |
| Three letter code: | H-Pro-Arg-Lys-Gly-Gly-Arg-Arg-Arg-Arg-Ala-Trp-Gly-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Ala-Pro-Arg-Lys-Arg-Leu-Thr-Leu-Ala-OH |
| Length (aa): | 40 |
| Peptide Purity (HPLC): | >95%; 98% and 99% purity available upon request |
| Quantity/Unit: | 1 Vial |
| * Optional Service: | TFA Removal Service is available upon request. |
Technical Information
| Source: | Synthetic |
| Storage Guidelines: | Store at -20°C for up to 1 year. should be refrigerated after reconstitution. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides |
| Solubility: | Soluble in water |
| Appearance: | White to off-white powder |
| Shipping: | Peptides are shipped at ambient temperature by standard shipment process. |
| About TFA salt: | Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA. TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others. It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR. TFA Removal Service is recommended for: > Peptides that will be used in cellular assays > Peptides that will be used as APIs or in manufactured products > For hydrophilic peptides containing numerous basic residues |
Related Products / Services
Custom Peptide Synthesis: ES2 peptide peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression. Read more...
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