ERG inhibitory peptide 2(EIP2)
For research use only. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.
Catalog Number: MPE0006277
Product Quantity: 5mg/20mg
Price: Varies
Availability: In Stock
Product Information
ERG inhibitory peptide 2, also known as EIP2 peptide was first reported in 'Development of Peptidomimetic Inhibitors of the ERG Gene Fusion Product in Prostate Cancer, Cancer Cell (2017)' by Wang et al. EIP2 peptide comprising the amino acid sequence: LSFGSLP. The EIP2 (LSFGSLP) was found to be homologous to the SR domain of DLC1 protein, which is encoded by a tumor suppressor gene often deleted in liver, prostate, lung, colorectal, and breast cancers. EIP1 & EIP2 peptide could bind ERG with high affinity and specificity, leading to proteolytic degradation of the ERG protein. The EIPs attenuated ERG-mediated transcription, chromatin recruitment, protein-protein interactions, cell invasion and proliferation, and tumor growth.
| Product Name: | ERG inhibitory peptide 2(EIP2) |
| Molecular Formula: | C34H54N8O9 |
| Molecular Weight: | 718.8 |
| Sequence: | H-LSFGSLP-NH2 |
| Three letter code: | H-Leu-Ser-Phe-Gly-Ser-Leu-Pro-NH2 |
| Length (aa): | 13 |
| Peptide Purity (HPLC): | >95%; 98% and 99% purity available upon request |
| Quantity/Unit: | 1 Vial |
| * Optional Service: | TFA Removal Service is available upon request. |
Technical Information
| Source: | Synthetic |
| Storage Guidelines: | Store at -20°C for up to 1 year. should be refrigerated after reconstitution. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides |
| Solubility: | Soluble in water |
| Appearance: | White to off-white powder |
| Shipping: | Peptides are shipped at ambient temperature by standard shipment process. |
| About TFA salt: | Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA. TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others. It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR. TFA Removal Service is recommended for: > Peptides that will be used in cellular assays > Peptides that will be used as APIs or in manufactured products > For hydrophilic peptides containing numerous basic residues |
Related Products / Services
Custom Peptide Synthesis: ERG inhibitory peptide 2(EIP2) peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression. Read more...
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