Drosocin peptide
For research use only. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.
Catalog Number: MPE0004035
Product Quantity: 5mg/20mg
Price: Varies
Availability: In Stock
Product Information
It is induced via the IMD pathway. Position T11 is o-glycosylated and important for full activity. Subsequent analysis showed that S7 may also be glycosylated. Turn elements occur near residues 4-7, 10-13, 17, and 18. At modorate concentrations, this peptide, as well as pyrrhocoricin (AP170), is also active against a few Gram-positive bacteria such as B. megaterium (44% homology to E. coli DnaK D-E helix) and M. luteus (Hoffmann R et al. 1999 Biochim Biophys Acta 1426:459-67). Mechanism of Action (MOA): It binds to an internal protein target DnaK (Eur J Biochem 2002; 269: 4226-4237). Note that all D-drosocin is inactive (so a non-membrane target) and the L form kills bacteria in hours not in minutes. Updated 12/2012 GW. Drosocin has Antibacterial activity. The source of Drosocin is Fruit fly, Drosophila melanogaster.
| Product Name: | Drosocin peptide |
| Sequence: | GKPRPYSPRPTSHPRPIRV |
| Three letter code: | Gly-Lys-Pro-Arg-Pro-Tyr-Ser-Pro-Arg-Pro-Thr-Ser-His-Pro-Arg-Pro-Ile-Arg-Val |
| Length (aa): | 19 |
| Peptide Purity (HPLC): | >95%; 98% and 99% purity available upon request |
| Quantity/Unit: | 1 Vial |
| * Optional Service: | TFA Removal Service is available upon request. |
Technical Information
| Source: | Synthetic |
| Storage Guidelines: | Store at -20°C for up to 1 year. should be refrigerated after reconstitution. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides |
| Solubility: | Soluble in water |
| Appearance: | White to off-white powder |
| Shipping: | Peptides are shipped at ambient temperature by standard shipment process. |
| About TFA salt: | Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA. TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others. It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR. TFA Removal Service is recommended for: > Peptides that will be used in cellular assays > Peptides that will be used as APIs or in manufactured products > For hydrophilic peptides containing numerous basic residues |
Related Products / Services
Custom Peptide Synthesis: Drosocin peptide peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression. Read more...
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