DRI-BCL10-P4 peptide
For research use only. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.
Catalog Number: MPE0008440
Product Quantity: 5mg/20mg
Price: Varies
Availability: In Stock
Product Information
DRI-BCL10-P4 is a BCL10 inhibitor peptide, interacted with BCL10, effectively disrupted BCL10 filament formation, selectively suppressed the growth of CB-SMOC-dependent cell lines (HBL1, TMD8 and SU-DHL4 cells), repressed NF-κB pathway activation in HBL1 and TMD8 cells but not in OCI-LY1 cells and induced apoptosis and cell cycle arrest of TMD8 and SU-DHL4 cells in a dose-dependent manner. DRI-BCL10-P4 suppressed the growth of BCL10-dependent DLBCL tumors in vivo. DRI-BCL10-P4 at 10 mg/kg significantly suppressed the growth of the BCL10-dependent cells (TMD8 and SU-DHL6 cell lines) but not the BCL10-independent tumor cells (OCI-LY1 cell line) in transplanted mouse models.
| Product Name: | DRI-BCL10-P4 peptide |
| Molecular Formula: | C194H320N64O49S |
| Molecular Weight: | 4365.06 |
| Sequence: | DRQIKIWFQNRRMKWKKeqlydllkGarkrsstr (lower case letters are on behalf of D-amino acid) |
| Three letter code: | H-Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-D-Glu-D-Gln-D-Leu-D-Tyr-D-Asp-D-Leu-D-Leu-D-Lys-Gly-D-Ala-D-Arg-D-Lys-D-Arg-D-Ser-D-Ser-D-Thr-D-Arg-OH |
| Length (aa): | 85 |
| Peptide Purity (HPLC): | >95%; 98% and 99% purity available upon request |
| Quantity/Unit: | 1 Vial |
| * Optional Service: | TFA Removal Service is available upon request. |
Technical Information
| Source: | Synthetic |
| Storage Guidelines: | Store at -20°C for up to 1 year. should be refrigerated after reconstitution. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides |
| Solubility: | Soluble in water |
| Appearance: | White to off-white powder |
| Shipping: | Peptides are shipped at ambient temperature by standard shipment process. |
| About TFA salt: | Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA. TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others. It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR. TFA Removal Service is recommended for: > Peptides that will be used in cellular assays > Peptides that will be used as APIs or in manufactured products > For hydrophilic peptides containing numerous basic residues |
Related Products / Services
Custom Peptide Synthesis: DRI-BCL10-P4 peptide peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression. Read more...
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