Cm-CATH2 peptide
For research use only. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.
Catalog Number: MPE0008558
Product Quantity: 5mg/20mg
Price: Varies
Availability: In Stock
Product Information
Cm-CATH2 is novel cathelicidin identified from green sea turtle. Cm-CATH2, exhibited potent, broad-spectrum and rapid bactericidal and anti-biofilm activities by inducing the disruption of cell membrane integrity. Additionally, Cm-CATH2 effectively induced the macrophages/monocytes and neutrophils trafficking to the infection site, and inhibited the LPS-induced production of inflammatory cytokines, by blocking TLR4/MD2 complex and the downstream signaling pathway activation. In mouse peritonitis and pneumonia models, Cm-CATH2 exhibited evident protection against drugresistant bacterial infections. Cm-CATH2 comprises an α-helix and two β-strands. Cm-CATH2 showed strong and broad-spectrum antimicrobial activity against almost all tested microorganisms, including clinically isolated Gram-positive bacteria, Gram-negative bacteria, fungi and aquatic pathogenic bacteria. The MICs of Cm-CATH2 against most tested strains were within 1.17–18.75μg/ml, especially for Shigella dysentery with MIC value of 1.17μg/ml. Cm-CATH2 at the concentration of 5×MIC required less than 30 min to kill all the tested microbes (E. faecium, E. coli, S. aureus, C. albicans and A. veronii). Especially for E. faecium, Cm-CATH2 showed strong lethal effect within 10 min at 5×MIC and 20 min at 1×MIC. However, the positive control meropenem at 5×MIC required at least 2 h to completely exterminate the E. faecium
| Product Name: | Cm-CATH2 peptide |
| Molecular Formula: | C181H307N69O38S |
| Molecular Weight: | 4089.86 |
| Sequence: | H-RRSRFGRFFKKVRKQLGRVLRHSRITVGGRMRF-OH |
| Three letter code: | H-Arg-Arg-Ser-Arg-Phe-Gly-Arg-Phe-Phe-Lys-Lys-Val-Arg-Lys-Gln-Leu-Gly-Arg-Val-Leu-Arg-His-Ser-Arg-Ile-Thr-Val-Gly-Gly-Arg-Met-Arg-Phe-OH |
| Length (aa): | 38 |
| Peptide Purity (HPLC): | >95%; 98% and 99% purity available upon request |
| Quantity/Unit: | 1 Vial |
| * Optional Service: | TFA Removal Service is available upon request. |
Technical Information
| Source: | Synthetic |
| Storage Guidelines: | Store at -20°C for up to 1 year. should be refrigerated after reconstitution. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides |
| Solubility: | Soluble in water |
| Appearance: | White to off-white powder |
| Shipping: | Peptides are shipped at ambient temperature by standard shipment process. |
| About TFA salt: | Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA. TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others. It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR. TFA Removal Service is recommended for: > Peptides that will be used in cellular assays > Peptides that will be used as APIs or in manufactured products > For hydrophilic peptides containing numerous basic residues |
Related Products / Services
Custom Peptide Synthesis: Cm-CATH2 peptide peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression. Read more...
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