Buforin II peptide
For research use only. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.
Catalog Number: MPE0006732
Product Quantity: 5mg/20mg
Price: Varies
Availability: In Stock
Product Information
Derived from buforin I after treatment with endoproteinase Lys-C. It displayed a more potent antimicrobial activity than its parent molecule. In TFE, buforin II contains a helix-hinge-helix structure with the first 4 aa disordered. A proline connects helix 1 (residues 5-10) and helix 2 (residues 12-21). MOA: It kills bacteria without lysing the cell. Instead, this peptide translocates aross bacterial membranes effectively. This is a typical peptide example that does not target bacterial membranes but internal targets such as nucleic acids. It has a strong affinity for DNA and RNA in vitro (Park et al 1998. Biochem Biophys Res Commun 244: 253-7). Both buforin II and its derivative buforin IIb (sequence: RAGLQFPVGRLLRRLLRRLLR) showed selective anticancer activity against 62 cancer cell lines (Lee 2008 Cancer Lett 271: 47-51). The sequence of histonin is RAGLQFPVGKLLKKLLKRLKR (updated 12/2008; Jan2013). Buforin II has Antibacterial, Antifungal activity. The source of Buforin II is Bufo bufo gargarizans, Asia.
| Product Name: | Buforin II peptide |
| Molecular Formula: | C106H184N40O26 |
| Molecular Weight: | 2434.8 |
| Sequence: | TRSSRAGLQFPVGRVHRLLRK |
| Three letter code: | H-Thr-Arg-Ser-Ser-Arg-Ala-Gly-Leu-Gln-Phe-Pro-Val-Gly-Arg-Val-His-Arg-Leu-Leu-Arg-Lys-OH |
| Length (aa): | 21 |
| Peptide Purity (HPLC): | >95%; 98% and 99% purity available upon request |
| Quantity/Unit: | 1 Vial |
| * Optional Service: | TFA Removal Service is available upon request. |
Technical Information
| Source: | Synthetic |
| Storage Guidelines: | Store at -20°C for up to 1 year. should be refrigerated after reconstitution. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides |
| Solubility: | Soluble in water |
| Appearance: | White to off-white powder |
| Shipping: | Peptides are shipped at ambient temperature by standard shipment process. |
| About TFA salt: | Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA. TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others. It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR. TFA Removal Service is recommended for: > Peptides that will be used in cellular assays > Peptides that will be used as APIs or in manufactured products > For hydrophilic peptides containing numerous basic residues |
Related Products / Services
Custom Peptide Synthesis: Buforin II peptide peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression. Read more...
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