APP 17mer peptide (204-220AA of APP695)
For research use only. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.
Catalog Number: MPE0009385
Product Quantity: 5mg/20mg
Price: Varies
Availability: In Stock
Product Information
APP 17mer peptide (204-220AA of APP695) is a 17–amino acid peptide corresponding to the GABABR1a(gamma-aminobutyric acid type B receptor subunit 1a) binding region within APP (Amyloid-beta precursor protein) suppressed in vivo spontaneous neuronal activity in the hippocampus of anesthetized Thy1-GCaMP6s mice. The sequence of APP 17mer peptide is: Ac-DDSDVWWGGADTDYADG-NH2. APP 17mer peptide could bind to sushi 1 domain of GABABR1a with a KD of 810 nM, in the same ragne as the binding affinity of the entire linker region. APP 17-mer peptide mimics the effects of sAPPα on GABABR1a dependent inhibition of synaptic vesicle release. Also, APP 17-mer peptide suppresses neuronal activity of CA1 pyramidal cells in vivo.
| Product Name: | APP 17mer peptide (204-220AA of APP695) |
| Molecular Formula: | C81H104N20O33 |
| Molecular Weight: | 1885.79 |
| Sequence: | Acetylation-DDSDVWWGGADTDYADG-Amidation |
| Three letter code: | Acetylation-Asp-Asp-Ser-Asp-Val-Trp-Trp-Gly-Gly-Ala-Asp-Thr-Asp-Tyr-Ala-Asp-Gly-Amidation |
| Length (aa): | 39 |
| Peptide Purity (HPLC): | >95%; 98% and 99% purity available upon request |
| Quantity/Unit: | 1 Vial |
| * Optional Service: | TFA Removal Service is available upon request. |
Technical Information
| Source: | Synthetic |
| Storage Guidelines: | Store at -20°C for up to 1 year. should be refrigerated after reconstitution. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides |
| Solubility: | Soluble in water |
| Appearance: | White to off-white powder |
| Shipping: | Peptides are shipped at ambient temperature by standard shipment process. |
| About TFA salt: | Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA. TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others. It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR. TFA Removal Service is recommended for: > Peptides that will be used in cellular assays > Peptides that will be used as APIs or in manufactured products > For hydrophilic peptides containing numerous basic residues |
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Custom Peptide Synthesis: APP 17mer peptide (204-220AA of APP695) peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression. Read more...
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