Alarin (human) peptide
For research use only. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.
Catalog Number: MPE0005252
Product Quantity: 5mg/20mg
Price: Varies
Availability: In Stock
Product Information
Alarin is derived from a splice variant of galanin-like peptide (GALP) RNA. It shows potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, as was also observed with other members of the galanin peptide family. Since alarin only shares five amino acids with GALP it is unlikely that the peptide can activate GALP-specific receptors. Originally discovered as neuropeptide in 2006 (Santic R et al 2006). It was termed alarin because of the N-terminal alanine and the C-terminal serine. In 2013, this peptide was demonstrated to have antimicrobial activity as well. Active against Gram-negative E. coli ML-35. Deletion of the conserved N-terminal sequence (APAHR) reduced its antimicrobial activity, suggesting that APAHR is essential for its antimicrobial activity. Electron microscopy showed that alarin caused bacterial membrane blebbing. Updated 11/26/2013. Alarin has Antibacterial activity. Alarin was found in brain, Homo sapiens.
| Product Name: | Alarin (human) peptide |
| Molecular Formula: | C127H205N43O35 |
| Molecular Weight: | 2894.29 |
| Sequence: | APAHRSSTFPKWVTKTERGRQPLRS |
| Three letter code: | H-Ala-Pro-Ala-His-Arg-Ser-Ser-Thr-Phe-Pro-Lys-Trp-Val-Thr-Lys-Thr-Glu-Arg-Gly-Arg-Gln-Pro-Leu-Arg-Ser-OH |
| Length (aa): | 25 |
| Peptide Purity (HPLC): | >95%; 98% and 99% purity available upon request |
| Quantity/Unit: | 1 Vial |
| * Optional Service: | TFA Removal Service is available upon request. |
Technical Information
| Source: | Synthetic |
| Storage Guidelines: | Store at -20°C for up to 1 year. should be refrigerated after reconstitution. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides |
| Solubility: | Soluble in water |
| Appearance: | White to off-white powder |
| Shipping: | Peptides are shipped at ambient temperature by standard shipment process. |
| About TFA salt: | Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA. TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others. It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR. TFA Removal Service is recommended for: > Peptides that will be used in cellular assays > Peptides that will be used as APIs or in manufactured products > For hydrophilic peptides containing numerous basic residues |
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Custom Peptide Synthesis: Alarin (human) peptide peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression. Read more...
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